In addition to the leading biomarkers mentioned above, ArtFun+ enalbes a precise quantification multiple other geometrical and flow measurements, including:
Diameter :
-Mean diameter (mm)
-Min diameter (mm
-Max diameter (mm)
-Diameter variation (%)
Area
Area (cm2): area delineated by the contour
-Minimal Area (cm²): minimal area along cardiac cycle
-Maximal Area (cm²): maximal area along cardiac cycle
-Positive flow area (cm2): pixellic area represented by positive velocity pixels inside the contour
-Negative flow area (cm2): pixellic area represented by negative velocity pixels inside the contour
Strain
Strain (%): ratio of the difference between max area and min area over min area
Blood Velocity measurements:
Velocity
-Mean Velocity (cm/s): mean velocity within the segmented vessel
-Minimum Velocity (cm/s): minimal velocity within the segmented vessel
-Maximum Velocity (cm/s): maximal velocity within the segmented vessel
Positive Velocity
-Mean Positive Velocity (cm/s): mean velocity considering only positive velocity pixels (physiological direction of flow) within the segmented vessel
-Minimum Positive Velocity (cm/s): minimal velocity considering only positive velocity pixels (physiological direction of flow) within the segmented vessel
-Maximum Positive velocity (cm/s): maximal velocity considering only positive velocity pixels (physiological direction of flow) within the segmented vessel
Negative Velocity
-Mean Negative Velocity (cm/s): mean velocity considering only negative velocity pixels (opposite of the physiological direction of flow) within the vessel
-Minimum Negative Velocity (cm/s): minimal velocity considering only negative velocity pixels (opposite of the physiological direction of flow) within the vessel
-Maximum Negative Velocity (cm/s): maximal velocity considering only negative velocity pixels (opposite of the physiological direction of flow) within the vessel
Blood Flow measurements:
-Flow (mL/s): flow within the segmented vessel
-Positive flow (mL/s): flow considering only positive velocity pixels (physiological direction of flow) within the segmented vessel
-Negative flow (mL/s): flow considering only negative velocity pixels (opposite of the physiological direction of flow) within the vessel
-Flow value at ejection peak (mL/s): maximal encountered flow value
-Backward Flow at peak (mL/s): idem Flow value at ejection peak, but on negative -flow-only curve
-Forward Flow at peak (mL/s): idem Flow value at ejection peak, but on positive-flow-only curve
-Ejection acceleration slope (mL/s2): slope between the ejection start point and ejection peak point
Blood Volumes measurements
-Acceleration volume (mL): blood volume between the section between the ejection start and the ejection peak
-Ejection volume (mL): blood volume between the section between the ejection start and the ejection end
-Regurgitation volume (mL): Negative blood volume between the ejection end and the regurgitation end
-Net volume (mL): net blood volume during the whole cardiac cycle
-Regurgitation fraction (%): ratio of the regurgitation volume over the net volume
-Backward Flow Ejection volume (mL): Ejection volume, but on negative flow components only
-Forward Flow Ejection volume (mL): Ejection volume, but on positive flow components only
-Backward Flow Net volume (mL): Net volume, but on negative flow only
-Forward Flow Net volume (mL): idem Net volume, but on positive flow only
Cardiac events
-Ejection start (ms): temporal position of the ejection beginning on the net flow curve
-Ejection peak (ms): temporal position of the ejection peak on net flow curve
-Ejection end (ms): temporal position of the ejection end on net flow curve
-Regurgitation end (ms): temporal position of the regurgitation end on net flow curve (if equal to ejection end, then there is no regurgitation)
-Delay from flow max peak to area max peak (ms): time delay between the ejection peak point (flow curve) and the maximal area point (area curve)
-Backward Flow Ejection start (ms): Ejection start on negative flow only
-Forward Flow Ejection start (ms): Ejection start on positive flow only
-Backward Flow Ejection peak (ms): Ejection peak on negative flow only
-Forward Flow Ejection peak (ms): Ejection peak on positive flow only
-Backward Flow Ejection end (ms): Ejection end on negative flow only curve
-Forward Flow Ejection end (ms): Ejection end on positive flow only
-Temporal % for Minimal Area: moment of cardiac cycle where the minimal area happens, in percent
-Temporal % for Maximal Area: moment of cardiac cycle where the maximal area happens, in percent
Confidence estimation
-Confidence estimation for %T_min: qualitative assessment of temporal position of minimal area
-Confidence estimation for %T_max: qualitative assessment of temporal position of maximal area
